Key details
Dr Solomon Habtemariam
Principal Lecturer, Pharmaceutical Sciences
Dr Solomon Habtemariam is a leading expert on drug discovery researches from natural sources. By using ethno-botanical information and bioassay-guided isolation studies, Dr Habtemariam's research has identified several classes of bioactive compounds. His in-house bioassay screens and expertise areas include:
- Targeting inflammatory cytokines and adhesion molecules by natural products
- Search for anti-microbial agents: antileishmanial, antibacterial and antifungal agents
- Identification of potential anti-cancer and immunomodulatory compounds
- Search for anticachexic agents from natural sources
- Modulation of reactive oxygen species in health and disease.
- Neurodegenerative diseases: principally Alzheimer's and Parkinson's diseases
- Identification of antidiabetic agents from plant sources
- Search of potential natural products that promote weight loss.
Hand-in-hand with the above-mentioned pharmacological assays, Dr Habtemariam uses chromatographic and spectroscopic analysis methods for standardising herbal products, i.e. he provides the scientific bases of traditional medicines through both chemical and pharmacological assays.
Recent publications
Article
Hadeiy, Seyed Kaveh , Habtemariam, Solomon, Shankayi, Zeinab, Shahyad, Shima , Sahraei, Hedayat , Asqardoost Rezaei, Milad , Bahrami, Farideh (2023), Amelioration of pain and anxiety in sleep-deprived rats by intra-amygdala injection of cinnamaldehyde. Elsevier. In: , , , . Elsevier, Sleep Medicine: X, 5: 100069 . pp. 1-8 ISSN: 2590-1427 (Print), (doi: https://doi.org/10.1016/j.sleepx.2023.100069).
Süntar, Ipek , Çetinkaya, Sümeyra, Haydaroğlu, Ülkü Selcen, Habtemariam, Solomon (2021), Bioproduction process of natural products and biopharmaceuticals: biotechnological aspects. Elsevier. In: , , , . Elsevier, Biotechnology Advances, 50: 107768 ISSN: 0734-9750 (Print), 1873-1899 (Online) (doi: https://doi.org/10.1016/j.biotechadv.2021.107768).
Hushmandi, Kiavash , Bokaie, Saied, Hashemi, Mehrdad, Moghadam, Ebrahim Rahmani , Raei, Mehdi , Hashemi, Farid , Bagheri, Mahdi , Habtemariam, Solomon , Nabavi, Seyed Mohammad (2020), A review of medications used to control and improve the signs and symptoms of COVID-19 patients. Elsevier. In: , , , . Elsevier, European Journal of Pharmacology, 887: 173568 ISSN: 0014-2999 (Print), 1879-0712 (Online) (doi: https://doi.org/10.1016/j.ejphar.2020.173568).
Fazel Nabavi, Seyed , Habtemariam, Solomon, Sureda, Antoni, Banach, Maciej , Berindan-Neagoe, Ioana , Andrei Cismaru, Cosmin , Bagheri, Mahdi , Sadegh Bagheri, Mohammad , Mohammad Nabavi, Seyed (2020), Glucose-6-phosphate dehydrogenase deficiency and SARS- CoV-2 mortality: Is there a link and what should we do?. Elsevier. In: , , , . Elsevier, Clinical Biochemistry, 86 . pp. 31-33 ISSN: 0009-9120 (Print), (doi: https://doi.org/10.1016/j.clinbiochem.2020.09.004) NB Item availability restricted.
Sahebnasagh, Adeleh , Saghafi, Fatemeh, Avan, Razieh, Khoshi, Amirhosein , Khataminia, Masoud , Safdari, Mohammadreza , Habtemariam, Solomon , Ghaleno, Hassan Rezai , Nabavi, Seyed Mohammad (2020), The prophylaxis and treatment potential of supplements for COVID-19. Elsevier. In: , , , . Elsevier, European Journal of Pharmacology, 887: 173530 . pp. 1-12 ISSN: 0014-2999 (Print), 1879-0712 (Online) (doi: https://doi.org/10.1016/j.ejphar.2020.173530) NB Item availability restricted.
Dowran, Razieh , Nabavi, Seyed Fazel, Habtemariam, Solomon, Banach, Maciej , Shahmohamadnejad, Shiva , Cismaru, Cosmin Andrei , Berindan-Neagoe, Ioana , Sahebnasagh, Adeleh , Nabavi, Seyed Mohammad (2020), Various interferon (IFN)-inducible transmembrane (IFITM) proteins for COVID-19, is there a role for the combination of mycophenolic acid and interferon?. Elsevier. In: , , , . Elsevier, Biochimie, 177 . pp. 50-52 ISSN: 0300-9084 (Print), (doi: https://doi.org/10.1016/j.biochi.2020.08.006) NB Item availability restricted.
Habtemariam, Solomon , Nabavi, Seyed Fazel, Ghavami, Saeid, Cismaru, Cosmin Andrei , Neagoe, Ioana Berindan , Nabavi, Seyed Mohammad (2020), Possible use of the mucolytic drug, bromhexine hydrochloride, as a prophylactic agent against SARS-CoV-2 infection based on its action on the Transmembrane Serine Protease 2. Elsevier. In: , , , . Elsevier, Pharmacological Research, 157: 104853 ISSN: 1043-6618 (Print), 1096-1186 (Online) (doi: https://doi.org/10.1016/j.phrs.2020.104853) NB Item availability restricted.
Jeandet, Philippe , Sobarzo-Sánchez, Eduardo, Silva, Ana Sanches, Clément, Christophe , Nabavi, Seyed Fazel , Battino, Maurizio , Rasekhian, Mahsa , Belwal, Tarun , Habtemariam, Solomon , Koffas, Mattheos (2019), Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives. Elsevier. In: , , , . Elsevier, Biotechnology Advances, 39: 107461 ISSN: 0734-9750 (Print), 1873-1899 (Online) (doi: https://doi.org/10.1016/j.biotechadv.2019.107461).
Shirooie, Samira , Nabavi, Seyed Fazel, Dehpour, Ahmad R., Belwal, Tarun , Habtemariam, Solomon , Argüelles, Sandro , Sureda, Antoni , Daglia, Maria , Tomczyk, Michał , Sobarzo-Sanchez, Eduardo (2018), Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?. Elsevier. In: , , , . Elsevier, Pharmacological Research, 135 . pp. 37-48 ISSN: 1043-6618 (Print), 1096-1186 (Online) (doi: https://doi.org/10.1016/j.phrs.2018.07.004).
Habtemariam, Solomon and , (2018), The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs. Medknow Publications. In: , , , . Medknow Publications, Neural Regeneration Research, 13 (6) . pp. 983-984 ISSN: 1673-5374 (Print), 1876-7958 (Online) (doi: https://doi.org/10.4103/1673-5374.233438).
Caputo, Leonardo , Quintieri, Laura, Cavalluzzi, Maria Maddalena, Lentini, Giovanni , Habtemariam, Solomon (2018), Antimicrobial and antibiofilm activities of citrus water-extracts obtained by microwave-assisted and conventional methods. MDPI. In: , , , . MDPI, Biomedicines, 6: 70 (2) 2227-9059 (Online) (doi: https://doi.org/10.3390/biomedicines6020070).
Habtemariam, Solomon and , Lentini, Giovanni (2018), Plant-derived anticancer agents: Lessons from the pharmacology of geniposide and its aglycone, genipin. MDPI. In: , , , . MDPI, Biomedicines, 6: 39 (2) 2227-9059 (Online) (doi: https://doi.org/10.3390/biomedicines6020039).
Mbatchou, Valentine Chi , Dickson, Rita Akosua, Amponsah, Isaac Kingsley, Mensah, Abraham Yeboah , Habtemariam, Solomon (2018), Protection effect of the anthraquinones, cassiatorin and aurantio-obtusin from seeds of Senna tora against cowpea weevil attack. Elsevier B.V.. In: , , , . Elsevier B.V., Asian Pacific Journal of Tropical Biomedicine ISSN: 2221-1691 (Print), 2588-9222 (Online) (doi: https://doi.org/10.4103/2221-1691.225620).
Habtemariam, Solomon and , (2018), Molecular pharmacology of rosmarinic and salvianolic acids: Potential seeds for Alzheimer’s and vascular dementia drugs.. MDPI. In: , , , . MDPI, International Journal of Molecular Sciences, 19: 458 (2) . pp. 458 ISSN: 1661-6596 (Print), 1422-0067 (Online) (doi: https://doi.org/10.3390/ijms19020458).
Habtemariam, Solomon and , (2018), Iridoids and other Mmnoterpenes in the Alzheimer’s Brain: Recent development and future prospects. MDPI. In: , , , . MDPI, Molecules, 23: 117 (1) ISSN: 1420-3049 (Print), (doi: https://doi.org/10.3390/molecules23010117).
Habtemariam, Solomon and , (2017), Could we really use aloe vera food supplements to treat diabetes? Quality control issues. Hindawi Publishing Corporation. In: , , , . Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine ISSN: 1741-427X (Print), 1741-4288 (Online) (doi: https://doi.org/10.1155/2017/4856412).
Belwal, Tarun , Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad, Habtemariam, Solomon (2017), Dietary anthocyanins and insulin resistance: When food becomes a medicine. MDPI. In: , , , . MDPI, Nutrients, 9: 1111 (10) ISSN: 2072-6643 (Print), (doi: https://doi.org/10.3390/nu9101111).
Habtemariam, Solomon and , (2017), Methodology for rapid isolation of Moringin: Potential anticancer compound from the seeds of Moringa stenopetala. OMICS International. In: , , , . OMICS International, Pharmaceutica Analytica Acta, 8: 1000558 (8) 2153-2435 (Online) (doi: https://doi.org/10.4172/2153-2435.1000558).
Elufioye, Taiwo Olayemi , Berida, Tomayo Ireti, Habtemariam, Solomon (2017), Plants-derived neuroprotective agents: Cutting the cycle of cell death through multiple mechanisms. Hindawi Publishing Corporation. In: , , , . Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine, 2017: 3574012 . pp. 1-27 ISSN: 1741-427X (Print), 1741-4288 (Online) (doi: https://doi.org/10.1155/2017/3574012).
Degennaro, Leonardo , Zenzola, Marina, Laurino, Annunziatina, Cavalluzzi, Maria Maddalena , Franchini, Carlo , Habtemariam, Solomon , Matucci, Rosanna , Luisi, Renzo , Lentini, Giovanni (2017), 2-Arylazetidines as ligands for nicotinic acetylcholine receptors. Springer US. In: , , , . Springer US, Chemistry of Heterocyclic Compounds, 53 (3) . pp. 329-334 ISSN: 0009-3122 (Print), 1573-8353 (Online) (doi: https://doi.org/10.1007/s10593-017-2061-5).
Gualdani, Roberta , Cavalluzzi, Maria, Lentini, Giovanni, Habtemariam, Solomon (2016), The chemistry and pharmacology of citrus limonoids. MDPI. In: , , , . MDPI, Molecules, 21: 1530 (11) . pp. 1-39 ISSN: 1420-3049 (Print), 1420-3049 (Online) (doi: https://doi.org/10.3390/molecules21111530).
Roselli, Mariagrazia , Cavalluzzi, Maria Maddalena, Bruno, Claudio, Lovece, Angelo , Carocci, Alessia , Franchini, Carlo , Habtemariam, Solomon , Lentini, Giovanni (2016), Synthesis and evaluation of berberine derivatives and analogues as potential anti-acetylcholinesterase and antioxidant agents. Elsevier. In: , , , . Elsevier, Phytochemistry Letters, 18 . pp. 150-156 ISSN: 1874-3900 (Print), 1876-7486 (Online) (doi: https://doi.org/10.1016/j.phytol.2016.10.005).
Habtemariam, Solomon and , (2016), Berberine and inflammatory bowel disease: A concise review. Elsevier. In: , , , . Elsevier, Pharmacological Research, 113 (Part A) . pp. 592-599 ISSN: 1043-6618 (Print), 1096-1186 (Online) (doi: https://doi.org/10.1016/j.phrs.2016.09.041).
Nabavi, Seyed Fazel , Maggi, Filippo, Daglia, Maria, Habtemariam, Solomon , Rastrelli, Luca , Nabavi, Seyed Mohammad (2016), Review: Pharmacological effects of Capparis spinosa L.. John Wiley & Sons, Ltd.. In: , , , . John Wiley & Sons, Ltd., Phytotherapy Research, 30 (11) . pp. 1733-1744 ISSN: 0951-418X (Print), 1099-1573 (Online) (doi: https://doi.org/10.1002/ptr.5684).
Roselli, Mariagrazia , Carocci, Alessia, Budriesi, Roberta, Micucci, Matteo , Toma, Maddalena , Di Cesare Mannelli, Lorenzo , Lovece, Angelo , Catalano, Alessia , Cavalluzzi, Maria Maddalena , Bruno, Claudio (2016), Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues. Elsevier Masson SAS. In: , , , . Elsevier Masson SAS, European Journal of Medicinal Chemistry, 121 . pp. 300-307 ISSN: 0223-5234 (Print), (doi: https://doi.org/10.1016/j.ejmech.2016.05.046).
Nabavi, Seyed Fazel , Habtemariam, Solomon, Di Lorenzo, Arianna, Sureda, Antoni , Khanjani, Sedigheh , Nabavi, Seyed Mohammad , Daglia, Maria (2016), Post-stroke depression modulation and in vivo antioxidant activity of gallic acid and its synthetic derivatives in a murine model system. MDPI. In: , , , . MDPI, Nutrients, 8 (5) . pp. 248 2072-6643 (Online) (doi: https://doi.org/10.3390/nu8050248).
Tsala, David Emery , Lannang, Alain Meli, Dimo, Theophile, Habtemariam, Solomon , Ekanga, Jean Arnaud , Guemmogne, Blandine Mbougen , Sewald, Norbert (2016), Antidiabetic and wound healing effects of smeathxanthone A. HATASO. In: , , , . HATASO, Recent Advances in Biology and Medicine, 2 . pp. 5-10 ISSN: 2378-654X (Print), (doi: https://doi.org/10.18639/RABM.2016.02.271146).
Habtemariam, Solomon and , (2016), The African Moringa is to change the lives of millions in Ethiopia and far beyond. Elsevier B.V.. In: , , , . Elsevier B.V., Asian Pacific Journal of Tropical Biomedicine, 6 (4) . pp. 355-356 ISSN: 2221-1691 (Print), (doi: https://doi.org/10.1016/j.apjtb.2015.12.016).
Habtemariam, Solomon and , (2016), Rutin as a natural therapy for Alzheimer’s disease: Insights into its mechanisms of action. Bentham Science Publishers. In: , , , . Bentham Science Publishers, Current Medicinal Chemistry, 23 (9) . pp. 860-873 ISSN: 0929-8673 (Print), (doi: https://doi.org/10.2174/0929867323666160217124333).
Nabavi, Seyed Fazel , Braidy, Nady, Habtemariam, Solomon, Sureda, Antoni , Manayi, Azadeh , Nabavi, Seyed Mohammad (2016), Neuroprotective effects of fisetin in Alzheimer’s and Parkinson's Diseases: From chemistry to medicine. Bentham Science Publishers. In: , , , . Bentham Science Publishers, Current Topics in Medicinal Chemistry, 16 (17) . pp. 1910-1915 ISSN: 1568-0266 (Print), 1873-4294 (Online) (doi: https://doi.org/10.2174/1568026616666160204121725).
Book
Habtemariam, Solomon and , (2017), The African and Arabian Moringa Species: Chemistry, Bioactivity and Therapeutic Applications. Elsevier. In: , , , . Elsevier, Oxford/Amsterdam (1st) . ISBN: 9780081022863 (doi: https://www.elsevier.com/books/the-african-and-arabian-moringa-species/habtemariam/978-0-08-102286-3).